Adler L T, Adler F L, Yamada A
Transplantation. 1978 Dec;26(6):401-6. doi: 10.1097/00007890-197812000-00007.
Long-lasting and stable lymphoid cell chimerism has been noted in three littermates of a group of five rabbits given injections at birth of spleen cells of an allotype-suppressed adult rabbit. The chimeric state manifested itself by the simultaneous display of light and heavy chain markers directed by donor and recipient genotypes in serum immunoglobulins (Ig), on blood lymphocytes, and on antibody molecules made in response to stimulation with three test antigens. Although the genotypes of two of the chimeras were found to be a1a1/b9b9 and the third to be a1a1/b6b9, phenotypically all three were a1a2/b5b6b9. By all of the criteria used to analyze to distribution of allotypes, Ig with the recipients' own allotypes predominated over that controlled by the donor's genotype. With only minor deviations the same proportions of recipient to donor types prevailed in total serum Ig and in the antibody fractions tested.
在一组五只兔子中，有三只同窝出生的兔子在出生时注射了异型抑制成年兔子的脾细胞，观察到了持久且稳定的淋巴细胞嵌合现象。嵌合状态表现为血清免疫球蛋白（Ig）、血液淋巴细胞以及针对三种测试抗原刺激产生的抗体分子上，同时展示出由供体和受体基因型指导的轻链和重链标记。尽管发现其中两只嵌合体的基因型为a1a1/b9b9，第三只为a1a1/b6b9，但在表型上，三只均为a1a2/b5b6b9。根据用于分析异型分布的所有标准，具有受体自身异型的Ig比受供体基因型控制的Ig占优势。在总血清Ig和测试的抗体组分中，受体型与供体型的比例仅存在微小偏差，基本相同。
