Adler F L, Adler L T
Cell Immunol. 1985 Apr 1;91(2):385-96. doi: 10.1016/0008-8749(85)90236-9.
In a model consisting of noninbred rabbits matched for major histocompatibility antigens and mismatched for immunoglobulin allotypes, using cell donors and recipients unrelated to each other, B-cell memory has been demonstrated to persist through three successive transfers for a period approaching 2 years. Memory cells from the original donor are shown to dominate specific antibody responses of the primary and secondary recipients. Vigorous antibody responses by donor-derived cells are obtained even when antigenic stimulation is delayed by several months. The data suggest that B memory cells may be particularly efficient in the colonization of recipients, and the potential significance of these findings for adoptive immunization of human bone marrow recipients is discussed.
在一个由主要组织相容性抗原匹配但免疫球蛋白同种异型不匹配的非近亲繁殖兔子组成的模型中，使用彼此无关的细胞供体和受体，已证明B细胞记忆可在连续三次转移中持续近2年。来自原始供体的记忆细胞在初次和二次受体的特异性抗体反应中占主导地位。即使抗原刺激延迟数月，供体来源的细胞也能产生强烈的抗体反应。数据表明，B记忆细胞在受体定植中可能特别有效，并讨论了这些发现对人类骨髓受体过继免疫的潜在意义。
