Adler L T, Adler F L
Transplantation. 1984 Oct;38(4):382-6. doi: 10.1097/00007890-198410000-00013.
Stable and lasting B lymphocyte chimerism induced in newborn rabbits through the introduction of spleen or lymph node cells from adult donors matched with the recipients for major histocompatibility antigens, is characterized by an apparent immunodeficiency of donor-derived cells. However, priming of the donor with an antigen that is subsequently used to immunize the recipients results in the selective and effective participation of donor cells in the chimera's antibody response to this antigen. These findings are ascribed to limitations in the repertoire of cells from the unprimed donor that colonize the recipients. Polyclonal stimulation secondary to allogeneic effects has been suggested as an explanation for the participation of donor-derived B cells noted in occasional recipients of cells from unprimed donors matched with recipients with respect to major but not minor histocompatibility antigens, and seen more regularly in surviving recipients of unmatched or mismatched donor cells.
通过引入与受体主要组织相容性抗原相匹配的成年供体的脾脏或淋巴结细胞，在新生兔中诱导出稳定且持久的B淋巴细胞嵌合体，其特征是供体来源的细胞存在明显的免疫缺陷。然而，用随后用于免疫受体的抗原对供体进行预刺激，会导致供体细胞选择性且有效地参与嵌合体对该抗原的抗体反应。这些发现归因于未预刺激的供体中定植于受体的细胞库存在局限性。对于主要但非次要组织相容性抗原与受体匹配的未预刺激供体细胞的偶尔受体中观察到的供体来源B细胞的参与，以及在不匹配或错配供体细胞的存活受体中更经常看到的情况，同种异体效应继发的多克隆刺激被认为是一种解释。
