Cowdery J S, Steinberg A D
Int Arch Allergy Appl Immunol. 1983;72(2):170-6. doi: 10.1159/000234861.
In vitro exposure of spleen cells to fetal calf serum prior to extensive washing and injection into syngeneic recipients was found to markedly increase in vitro responses to both trinitrophenyl-Ficoll and sheep erythrocytes, increase in vitro spontaneous (background) direct plaque-forming cell responses, and cause a tenfold increase in spontaneous IgM production in vitro. This study demonstrates T cell mediated polyclonal B cell activation which was manifested both in vitro and in vivo.
在对脾细胞进行广泛洗涤并注射到同基因受体之前，先将其在体外暴露于胎牛血清中，结果发现这会显著增强对三硝基苯基 - 菲可和绵羊红细胞的体外反应，增加体外自发（背景）直接空斑形成细胞反应，并使体外自发IgM产生增加十倍。这项研究证明了T细胞介导的多克隆B细胞活化，这在体外和体内均有表现。
