De Leon M J, Ferris S H, George A E, Reisberg B, Kricheff I I, Gershon S
Neurobiol Aging. 1980 Summer;1(1):69-79. doi: 10.1016/0197-4580(80)90027-5.
Neuropathological investigations have demonstrated brain-behavior relationships in senile dementia of the Alzheimer's type (SDAT), but CT studies have not produced consistent findings. We hypothesized that these discouraging results were in part due to limitations in the methods of CT scan evaluations, and to non-homogeneity of patient populations. The present study examined 43 out-patients with the presumptive diagnosis of SDAT using 37 cognitive test measures and 3 independent CT evaluation strategies. The CT methods included a new rank ordering procedure and two previously used techniques, physical measurement and 4-point rating. Highly significant (p less than or equal to 0.01) brain-behavior correlations were attained using the ranking and rating procedures for evaluation of ventricular and cortical pathology. It was found that rank ordering has high interrater reliability and is superior to the other methods for the evaluation of the ventricular system. The physical measurement of the third ventricle is the single most powerful linear correlate of cognitive impairment. Measurement of cortical sulci are of no correlational significance. Multiple regression analyses indicated that global assessments are the best cognitive predictors of both ventricular and cortical pathology. Thus the present study has demonstrated brain-behavior relationships in vivo in SDAT.
神经病理学研究已经证实了阿尔茨海默型老年痴呆症（SDAT）中脑与行为的关系，但CT研究尚未得出一致的结果。我们推测，这些令人沮丧的结果部分归因于CT扫描评估方法的局限性以及患者群体的非同质性。本研究使用37项认知测试指标和3种独立的CT评估策略，对43名初步诊断为SDAT的门诊患者进行了检查。CT方法包括一种新的排序程序以及两种先前使用的技术，即物理测量和4分评分法。使用排序和评分程序评估脑室和皮质病变时，获得了高度显著（p小于或等于0.01）的脑与行为相关性。结果发现，排序具有较高的评分者间信度，并且在评估脑室系统方面优于其他方法。第三脑室的物理测量是认知障碍最有力的单一线性相关指标。皮质沟回的测量没有相关性意义。多元回归分析表明，整体评估是脑室和皮质病变的最佳认知预测指标。因此，本研究已经在活体中证实了SDAT中脑与行为的关系。
