一例具有成人T细胞白血病相关抗原抗体的T细胞源性慢性淋巴细胞白血病病例报告。
A report of a case of T-cell-derived chronic lymphocytic leukemia with antibodies to adult T-cell leukemia-associated antigens.
作者信息
Utsunomiya A, Matsumoto M, Matsumoto T, Nishioka K, Iwahashi M, Hanada S, Nomura K, Hashimoto S, Yunoki K
出版信息
Jpn J Clin Oncol. 1983;13 Suppl 2:291-9.
A case of T-cell-derived chronic lymphocytic leukemia (T-CLL) with antibodies to adult T-cell leukemia (ATL)-associated antigens (ATLA) is reported. The patient had marked lymphocytosis consisting of peripheral cells that were shown to be T cells by their spontaneous sheep erythrocyte rosette formation and their OKT3 and OKT8 positivity, and in which ATLA were also detected after short-term culture of the cells in vitro. These findings suggest that adult T-cell leukemia virus (ATLV) might cause not only ATL but also some other lymphoid malignancies such as a type of T-CLL as in this case report. Nevertheless the occasional development of OKT8-positive T-CLL in a healthy carrier of ATLV in an ATL-endemic area cannot be disregarded.
报告了一例T细胞来源的慢性淋巴细胞白血病（T-CLL），该患者体内存在针对成人T细胞白血病（ATL）相关抗原（ATLA）的抗体。患者外周血淋巴细胞显著增多，通过自发形成绵羊红细胞花环以及OKT3和OKT8阳性证实这些外周细胞为T细胞，并且在体外短期培养这些细胞后也检测到了ATLA。这些发现提示成人T细胞白血病病毒（ATLV）可能不仅导致ATL，还可能引起其他一些淋巴系统恶性肿瘤，如本病例报告中的一种T-CLL。然而，在ATL流行地区，健康的ATLV携带者偶尔发生OKT8阳性T-CLL这一情况也不容忽视。
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