Sorjonen D C, Dillon A R, Powers R D, Spano J S
Am J Vet Res. 1983 Jul;44(7):1233-7.
Effects of dexamethasone and surgical hypotension on the gastric mucosa of 15 dogs was evaluated by clinical, endoscopic, and pathologic studies. Dexamethasone produced acute reddening of the gastric mucosa with frank hemorrhage, digested blood, and possible gastric erosions, whereas dogs treated by surgical hypotension did not have marked changes in the gastric mucosa. Gastrointestinal disease observed in dogs with spontaneous spinal cord injury that were given dexamethasone and decompressive spinal surgery was not produced. The role of corticosteroids and surgical hypotension in the pathogenesis of gastric lesions and the potential for spinal cord injury to produce gastrointestinal disease is discussed.
通过临床、内镜及病理研究评估了地塞米松和手术性低血压对15只犬胃黏膜的影响。地塞米松可导致胃黏膜急性发红，并伴有明显出血、消化性血液及可能的胃糜烂，而接受手术性低血压治疗的犬胃黏膜未出现明显变化。给予地塞米松和减压性脊柱手术的自发性脊髓损伤犬未出现所观察到的胃肠道疾病。讨论了皮质类固醇和手术性低血压在胃损伤发病机制中的作用以及脊髓损伤产生胃肠道疾病的可能性。
