免疫异常与乙内酰脲类药物
Immunological abnormalities and hydantoins.
作者信息
Grob P J, Herold G E
出版信息
Br Med J. 1972 Jun 3;2(5813):561-3. doi: 10.1136/bmj.2.5813.561.
Abstract
Various immunological features were measured in 20 patients with epilepsy who had received prolonged treatment with hydantoins. Immunoglobulin A (IgA) was shown to be absent or low in five patients, beta(1)C/A was low in 10 patients. Five patients showed negative reactions to skin tests, and two could not be sensitized to dinitrochlorobenzene. The corresponding features were normal in 14 control patients with epilepsy but without hydantoins. It is suggested that the hydantoins influence humoral immunity, whereas other immunosuppressant agents have been found to affect cellular immunity.
摘要
对20名接受过长期苯妥英治疗的癫痫患者的各种免疫学特征进行了检测。结果显示，5名患者的免疫球蛋白A（IgA）缺失或水平较低，10名患者的β(1)C/A水平较低。5名患者的皮肤试验呈阴性反应，2名患者对二硝基氯苯无法产生致敏反应。14名未接受苯妥英治疗的对照癫痫患者的相应特征均正常。研究表明，苯妥英会影响体液免疫，而其他免疫抑制剂则被发现会影响细胞免疫。
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本文引用的文献
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