McCrea E S, Johnston C, Haney P J
AJR Am J Roentgenol. 1983 Oct;141(4):685-90. doi: 10.2214/ajr.141.4.685.
Metastases to the breast are uncommon, with about 250 cases reported from clinical and autopsy series. The mammographic findings in 16 new cases revealed a spectrum of changes that included solitary or multiple lesions, well demarcated or poorly marginated masses, and diffuse involvement of skin or parenchyma or both. Diffuse disease was seen more frequently in this series (4/16), at times simulating inflammatory breast cancer. Although diagnosis of a primary malignancy usually preceded detection of the breast lesion, 40% (6/16) had no history of malignancy. Prognosis remains poor; however, it has improved in the lymphoma-leukemia group due to improved immunotherapeutic and chemotherapeutic regimens. The clinical, radiologic, and pathologic features are discussed. Some of the lesions encountered can be confused with a primary breast malignancy or a benign lesion, necessitating prompt and accurate biopsy to preclude unnecessary major surgery and to improve survival in cancers amenable to current therapy.
乳腺转移瘤并不常见，临床和尸检系列报道的病例约有250例。16例新病例的乳腺钼靶检查结果显示出一系列变化，包括单发或多发病变、边界清晰或边界不清的肿块，以及皮肤或实质或两者的弥漫性受累。在该系列中，弥漫性病变更为常见（4/16），有时类似炎性乳腺癌。虽然原发性恶性肿瘤的诊断通常先于乳腺病变的发现，但40%（6/16）没有恶性肿瘤病史。预后仍然很差；然而，由于免疫治疗和化疗方案的改进，淋巴瘤-白血病组的预后有所改善。本文讨论了其临床、放射学和病理学特征。所遇到的一些病变可能与原发性乳腺恶性肿瘤或良性病变相混淆，因此需要及时准确的活检，以避免不必要的大手术，并提高适合当前治疗的癌症患者的生存率。
