金黄色葡萄球菌对某些头孢菌素的耐药机制
Mechanism of resistance to some cephalosporins in Staphylococcus aureus.
作者信息
Kono M, Sasatsu M, O'Hara K, Shiomi Y, Hayasaka T
出版信息
Antimicrob Agents Chemother. 1983 Jun;23(6):938-40. doi: 10.1128/AAC.23.6.938.
Abstract
The mechanism of resistance to some cephalosporins in Staphylococcus aureus strains was investigated with high-pressure liquid chromatography and nuclear magnetic resonance spectrometry. Drug inactivation by penicillinase was found to be the main mechanism of resistance to cefazolin, cephaloridine, and cephalothin in S. aureus.
摘要
采用高压液相色谱法和核磁共振光谱法，对金黄色葡萄球菌菌株对某些头孢菌素的耐药机制进行了研究。发现青霉素酶使药物失活是金黄色葡萄球菌对头孢唑林、头孢噻啶和头孢噻吩耐药的主要机制。
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本文引用的文献
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FEBS Lett. 1980 Dec 29;122(2):275-8. doi: 10.1016/0014-5793(80)80455-8.
2
Penicillin-binding proteins in a Staphylococcus aureus strain resistant to specific beta-lactam antibiotics.一株对特定β-内酰胺类抗生素耐药的金黄色葡萄球菌中的青霉素结合蛋白
Antimicrob Agents Chemother. 1982 Jul;22(1):172-5. doi: 10.1128/AAC.22.1.172.
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Antimicrob Agents Chemother. 1982 Jun;21(6):925-34. doi: 10.1128/AAC.21.6.925.
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Binding of beta-lactam antibiotics to penicillin-binding proteins of Staphylococcus aureus and Streptococcus faecalis: relation to antibacterial activity.β-内酰胺类抗生素与金黄色葡萄球菌和粪肠球菌青霉素结合蛋白的结合：与抗菌活性的关系。
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