人脐带血淋巴细胞介导针对流感病毒感染细胞的抗体依赖性细胞毒性的能力。
Ability of human cord blood lymphocytes to mediate antibody-dependent cellular cytotoxicity against influenza virus-infected cells.
作者信息
Hashimoto G, Wright P F, Karzon D T
出版信息
Infect Immun. 1983 Oct;42(1):214-8. doi: 10.1128/iai.42.1.214-218.1983.
Abstract
Cord blood lymphocytes, monocytes, and neutrophils from newborns were shown to mediate antibody-dependent cellular cytotoxicity (ADCC) against influenza virus-infected cells. Antibody mediating ADCC was detectable in cord plasma, indicating that all components necessary for ADCC against influenza virus-infected cells are present in newborns. Among adult lymphocytes, two effector cell populations of influenza ADCC are recognized: non-T and T gamma cells. Each of these cell types expresses an antigen recognized by monoclonal HNK-1 antibody. The proportion of HNK-1 antigen-positive lymphocytes in cord blood was markedly lower than in adult blood; furthermore, ADCC was mediated by cord blood lymphocytes which were HNK-1 negative. By lymphocyte fractionation, the effector lymphocytes in cord blood were, as in adults, non-T and T gamma cells, suggesting that HNK-1 antigen is not expressed on these cell lineages in newborns.
摘要
已证明新生儿的脐血淋巴细胞、单核细胞和中性粒细胞可介导针对流感病毒感染细胞的抗体依赖性细胞毒性（ADCC）。在脐血浆中可检测到介导ADCC的抗体，这表明针对流感病毒感染细胞的ADCC所需的所有成分在新生儿中均存在。在成人淋巴细胞中，可识别出两种流感ADCC效应细胞群：非T细胞和Tγ细胞。这些细胞类型中的每一种都表达一种可被单克隆HNK-1抗体识别的抗原。脐血中HNK-1抗原阳性淋巴细胞的比例明显低于成人血液；此外，ADCC由HNK-1阴性的脐血淋巴细胞介导。通过淋巴细胞分级分离，脐血中的效应淋巴细胞与成人一样，为非T细胞和Tγ细胞，这表明新生儿的这些细胞谱系上不表达HNK-1抗原。
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