Serio C S, Henning C B, Toohey R E, Lloyd E L
Int J Radiat Biol Relat Stud Phys Chem Med. 1983 Sep;44(3):251-6. doi: 10.1080/09553008314551111.
Mitogenic stimulation of peripheral blood lymphocyte cultures obtained from 36 thorium workers was studied to determine whether the response of these cells was affected by the individuals' occupational exposure to alpha irradiation. The standard assay involved incubating 2 X 10(5) lymphocytes per test well for 72 hours in the presence of phytohemagglutinin (PHA), concanavalin A (Con A) or pokeweed mitogen (PWM). The results showed that there was a significant decrease in lymphocyte responsiveness of former thorium workers grouped by decade of life when compared with controls of the same decade of life for each mitogen tested with the exceptions of PHA in the 41-50 age group and PWM in the 51-60 age group. We are unable to correlate the decreased response observed with the measured body burdens, external gamma exposure, or thoron exhalation rates in these thorium cases. However, other occupational exposures (i.e., various chemicals used in processing thorium) cannot be eliminated as a possible cause.
对36名钍作业工人外周血淋巴细胞培养物的有丝分裂刺激进行了研究，以确定这些细胞的反应是否受到个体职业性α辐射暴露的影响。标准检测方法包括在植物血凝素（PHA）、刀豆球蛋白A（Con A）或商陆有丝分裂原（PWM）存在的情况下，每个测试孔中孵育2×10⁵个淋巴细胞72小时。结果显示，按生活年代分组的前钍作业工人，与相同生活年代的对照组相比，在所测试的每种有丝分裂原刺激下，淋巴细胞反应性均显著降低，但41 - 50岁年龄组的PHA和51 - 60岁年龄组的PWM除外。在这些钍作业病例中，我们无法将观察到的反应降低与测量的体内负荷、外部γ辐射暴露或钍射气呼出率相关联。然而，其他职业暴露（即钍加工过程中使用的各种化学物质）作为可能的原因不能排除。
