Carstensen J T, Wright J L, Blessel K, Sheridan J
J Pharm Sci. 1978 Jul;67(7):982-4. doi: 10.1002/jps.2600670730.
The dissolution of a rapidly soluble, finely subdivided substance in a directly compressed tablet and in a wet granulated tablet was treated experimentally and compared with previous theoretical models. The dissolution curves were sigmoid with a semilogarithmic tail when concentration was plotted versus time. As predicted, the slope of the semilogarithmic plots were related to the disintegration decay constant for tablet erosion in the basket.
对速溶、细分物质在直接压片和湿法制粒片中的溶解情况进行了实验处理，并与先前的理论模型进行了比较。当绘制浓度与时间的关系图时，溶解曲线呈S形且带有半对数尾部。正如预测的那样，半对数图的斜率与篮法中片剂溶蚀的崩解衰减常数有关。
