Carstensen J T, Wright J L, Blessel K W, Sheridan J
J Pharm Sci. 1978 Jan;67(1):48-50. doi: 10.1002/jps.2600670113.
The basic steps involved in the dissolution of a directly compressed tablet in a USP basket dissolution apparatus were examined via data generation. The proposed model explains why a dissolution curve can be sigmoid shaped and why the portion past the lag time has a log-linear undissolved mass versus time correlation.
通过数据生成，研究了直接压片在USP篮式溶出装置中溶解所涉及的基本步骤。所提出的模型解释了为什么溶出曲线可以呈S形，以及为什么滞后时间之后的部分具有未溶解质量与时间的对数线性相关性。
