Sengupta S R, Dhole T N, Jahagirdar V L, Yemul V L, Chawhan R N
Lepr India. 1983 Apr;55(2):242-6.
In our earlier study (Yemul et, al, 1983) we have reported elevation of serum alpha one antitrypsin levels in patients of lepromatous leprosy and lepra reaction. In this study estimation of serum alpha one antitrypsin levels in fifty lepra reaction patients (8 of type 1 and 42 of type II) and fifty age and sex matched healthy controls is described. Alpha one antitrypsin levels were elevated in lepra reaction patients (type I--mean value of 332 mg% and S.D. +/- 118.8 and type II--mean value of 450 mg% and S.D. +/- 73.7) when compared with the healthy controls (mean value of 285 mg% and S.D. +/- 66.05). The increase in levels in type II lepra reaction patients was statistically significant. The results are discussed to correlate the increased levels of alpha one antitrypsin and the high bacterial load leading to the release of various proteases in type II lepra reaction.
在我们早期的研究中（耶穆尔等人，1983年），我们报告了瘤型麻风病患者和麻风反应患者血清α1抗胰蛋白酶水平升高。本研究描述了对50例麻风反应患者（1型8例，II型42例）以及50名年龄和性别相匹配的健康对照者血清α1抗胰蛋白酶水平的测定。与健康对照者（平均值为285mg%，标准差±66.05）相比，麻风反应患者（1型——平均值为332mg%，标准差±118.8；II型——平均值为450mg%，标准差±73.7）的α1抗胰蛋白酶水平升高。II型麻风反应患者的水平升高具有统计学意义。对α1抗胰蛋白酶水平升高与II型麻风反应中导致各种蛋白酶释放的高菌量之间的相关性进行了讨论。
