阿司匹林、芬布芬与安慰剂所致胃肠道微出血的对比研究。
Comparative study of gastrointestinal microbleeding caused by aspirin, fenbufen, and placebo.
作者信息
Lussier A, Tétreault L, Lebel E
出版信息
Am J Med. 1983 Oct 31;75(4B):80-3. doi: 10.1016/0002-9343(83)90333-9.
Fifty volunteers, randomly divided into five groups, received placebo, fenbufen, or aspirin at dosages used in treating osteoarthritis and rheumatoid arthritis (fenbufen, 600 or 900 mg daily; aspirin, 3.6 g daily) for 28 days. Following radioactive chromium labeling of red cells in each subject, stool specimens were collected weekly for determination of blood loss by radioisotope procedure. Statistical analyses demonstrated no significant differences in gastrointestinal microbleeding between subjects who received fenbufen (600 or 900 mg daily) and those who received placebo. Conversely, there were significant (p less than 0.01) differences in microbleeding between subjects given aspirin and those given either dosage of fenbufen or placebo.
五十名志愿者被随机分成五组，分别接受安慰剂、芬布芬或阿司匹林治疗，剂量为治疗骨关节炎和类风湿性关节炎时的常用剂量（芬布芬，每日600或900毫克；阿司匹林，每日3.6克），为期28天。在对每个受试者的红细胞进行放射性铬标记后，每周收集粪便样本，通过放射性同位素程序测定失血量。统计分析表明，接受芬布芬（每日600或900毫克）的受试者与接受安慰剂的受试者在胃肠道微出血方面无显著差异。相反，服用阿司匹林的受试者与服用任一剂量芬布芬或安慰剂的受试者在微出血方面存在显著差异（p小于0.01）。
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