Kojo H, Nishida M, Goto S, Kuwahara S
Antimicrob Agents Chemother. 1979 Nov;16(5):549-53. doi: 10.1128/AAC.16.5.549.
Antibacterial activity of FK 749 against ampicillin-resistant clinical isolates of Escherichia coli was compared with those of other newly developed cephalosporins. FK 749 was the most active against strains possessing R-plasmids specifying ampicillin resistance and those whose resistance was chromosomally determined. The susceptibility of ampicillin-susceptible E. coli to FK 749 was not decreased by transduction of ampicillin resistance-specifying plasmids. However, most of the transconjugants acquired a high level of resistance to cefoperazone and cefamandole and a moderate level of resistance to cefoperazone and cefamandole and a moderate level to cefotiam. FK 749 was highly stable to both penicillinase- and cephalosporinase-type beta-lactamases, including R-plasmid-mediated beta-lactamase. Its level of resistance to beta-lactamases was comparable to those of cefoxitin, cefmetazole, and cefotaxime, slightly superior to that of cefuroxime, and much superior to those of cefotiam, cefamandole, and cefoperazone.
将FK 749对耐氨苄西林临床分离大肠杆菌的抗菌活性与其他新开发的头孢菌素进行了比较。FK 749对携带指定氨苄西林抗性的R质粒的菌株以及那些抗性由染色体决定的菌株活性最强。通过转导指定氨苄西林抗性的质粒，氨苄西林敏感的大肠杆菌对FK 749的敏感性并未降低。然而，大多数转接合子对头孢哌酮和头孢孟多获得了高水平抗性，对头孢替安获得了中等水平抗性。FK 749对青霉素酶型和头孢菌素酶型β-内酰胺酶高度稳定，包括R质粒介导的β-内酰胺酶。其对β-内酰胺酶的抗性水平与头孢西丁、头孢美唑和头孢噻肟相当，略优于头孢呋辛，远优于头孢替安、头孢孟多和头孢哌酮。
