Broadie T A, Herman C M
J Trauma. 1978 Jun;18(6):381-6. doi: 10.1097/00005373-197806000-00001.
The oxygen delivery capacity of fresh whole blood was compared with that of 21-day-old blood in an isolated, perfused canine hindlimb preparation. At the outset, 21-day-old blood was found to have depressed levels of 2,3 DPG and higher p50's relative to those of freshly procured blood, implying an increased oxygen affinity of the former product. Despite this, oxygen consumption from 21-day-old blood was not demonstrated to be significantly different than that from fresh blood. It is concluded that significant improvement in oxygen delivery capacity alone should not be construed as justification for the choice of fresh over older blood clinical replacement therapy.
在一个孤立的、灌注的犬后肢制备模型中，对新鲜全血和保存21天的血液的氧输送能力进行了比较。一开始，发现保存21天的血液中2,3-二磷酸甘油酸（2,3 DPG）水平降低，相对于新鲜采集的血液，其P50值更高，这意味着前者的氧亲和力增加。尽管如此，保存21天的血液的氧消耗量与新鲜血液相比并无显著差异。得出的结论是，仅氧输送能力的显著提高不应被视为在临床替代治疗中选择新鲜血液而非陈旧血液的理由。
