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环磷酰胺对NZB/NZW小鼠肾小球通透性及免疫反应物定位的影响。

Effect of cyclophosphamide on glomerular permeability and localization of immunoreactants in NZB/NZW mice.

作者信息

Czechner O I, Cavallo T

出版信息

Clin Exp Immunol. 1982 Apr;48(1):79-84.

PMID:6211318
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1536566/
Abstract

We investigated the effect of cyclophosphamide on glomerular permeability and deposition of immunoreactants in NZB/W mice. Glomerular permeability, assessed by proteins excreted in the urine and by a molecular probe of anionic sites, remained unaltered, compared to pretreatment studies, and deposits of immunoreactants were mesangial and decreased overall, in comparison to untreated NZB/W mice. Therapy with cyclophosphamide may prevent deterioration of glomerular filtration characteristics by interfering with factors that favour the deposition of immunoreactants in the glomerular capillary wall.

摘要

我们研究了环磷酰胺对NZB/W小鼠肾小球通透性及免疫反应物沉积的影响。与预处理研究相比，通过尿中排泄的蛋白质和阴离子位点分子探针评估的肾小球通透性未发生改变，并且与未治疗的NZB/W小鼠相比，免疫反应物沉积位于系膜区且总体减少。环磷酰胺治疗可能通过干扰有利于免疫反应物在肾小球毛细血管壁沉积的因素来预防肾小球滤过特性的恶化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2729/1536566/4c2ea5df7291/clinexpimmunol00169-0095-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2729/1536566/27019bfd1205/clinexpimmunol00169-0095-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2729/1536566/cbee5018f5d7/clinexpimmunol00169-0095-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2729/1536566/df129051ca34/clinexpimmunol00169-0095-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2729/1536566/4c2ea5df7291/clinexpimmunol00169-0095-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2729/1536566/27019bfd1205/clinexpimmunol00169-0095-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2729/1536566/cbee5018f5d7/clinexpimmunol00169-0095-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2729/1536566/df129051ca34/clinexpimmunol00169-0095-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2729/1536566/4c2ea5df7291/clinexpimmunol00169-0095-d.jpg

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Clin Exp Immunol. 1982 Apr;48(1):79-84.
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引用本文的文献

1
Murine lupus nephritis: effect of azathioprine on glomerular permeability and localization of immunoreactants.小鼠狼疮性肾炎：硫唑嘌呤对肾小球通透性及免疫反应物定位的影响
Clin Exp Immunol. 1983 Sep;53(3):547-54.
2
Murine lupus nephritis: effects of cyclophosphamide on circulating and tissue bound immunoreactants.小鼠狼疮性肾炎：环磷酰胺对循环及组织结合免疫反应物的影响
Clin Exp Immunol. 1984 Jan;55(1):67-73.
3
Cyclophosphamide and 15(S)-15 methyl PGE1 correct the T/B lymphocyte ratios of NZB/NZW mice.环磷酰胺和15(S)-15甲基前列腺素E1可纠正NZB/NZW小鼠的T/B淋巴细胞比例。

本文引用的文献

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Glomerular permeability. Ultrastructural studies in New Zealand black/white mice using polyanionic ferritin as a molecular probe.肾小球通透性。以多阴离子铁蛋白作为分子探针，对新西兰黑/白小鼠进行的超微结构研究。
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