Kloster B E, Tomar R H, Spira T J
Clin Immunol Immunopathol. 1984 Feb;30(2):330-5. doi: 10.1016/0090-1229(84)90066-7.
The acquired immune deficiency syndrome (AIDS) manifested by opportunistic infections or Kaposi's sarcoma is a newly recognized and often fatal disease. Three patients seen in Syracuse, New York, were noted to have lymphopenia and persistent serum lymphocytotoxic antibodies (LCTAs). In a double blinded study, 25 serum samples were coded and sent to us by the Centers for Disease Control Task Force on Kaposi's Sarcoma and Opportunistic Infections. Samples from 5 patients with Pneumocystis carinii pneumonia, 5 patients with Kaposi's sarcoma, 5 presumably healthy homosexual males, 5 presumably healthy heterosexual males, and 5 presumably healthy heterosexual females were included. Of the ten AIDS patients, nine had "positive" or "suspicious" results on testing for lymphocytotoxic antibodies. The five heterosexual male and five heterosexual female controls had "negative" results. Of the five homosexual male "controls," three had "positive" or "suspicious" LCTA results. Two of these three "controls" were available for follow-up. Both showed deficiencies in studies of their cell-mediated immunity. Lymphocytotoxic antibodies may participate in the ongoing immunodeficiency seen in AIDS.
由机会性感染或卡波西肉瘤所表现出的获得性免疫缺陷综合征（艾滋病）是一种新发现的、往往致命的疾病。在纽约州锡拉丘兹市见到的三名患者被发现有淋巴细胞减少症和持续存在的血清淋巴细胞毒性抗体（LCTAs）。在一项双盲研究中，25份血清样本被编码，并由疾病控制中心卡波西肉瘤和机会性感染特别工作组寄送给我们。样本包括来自5名卡氏肺孢子虫肺炎患者、5名卡波西肉瘤患者、5名据推测健康的同性恋男性、5名据推测健康的异性恋男性以及5名据推测健康的异性恋女性。在这10名艾滋病患者中，9人在淋巴细胞毒性抗体检测中呈“阳性”或“可疑”结果。5名异性恋男性和5名异性恋女性对照者的检测结果为“阴性”。在5名同性恋男性“对照者”中，3人LCTA检测结果呈“阳性”或“可疑”。这3名“对照者”中有2人可供随访。两人在细胞介导免疫研究中均显示出缺陷。淋巴细胞毒性抗体可能参与了艾滋病中所见的持续免疫缺陷过程。
