Klugo R C, Cerny J C
J Urol. 1978 May;119(5):667-8. doi: 10.1016/s0022-5347(17)57584-9.
Five patients were treated with gonadotropin and topical testosterone for micropenis associated with hypothalamic hypogonadotropic hypogonadism. All patients received 1,000 units of gonadotropin weekly for 3 weeks, with a 6-week interval followed by 10% topical testosterone cream twice daily for 3 weeks. Serum testosterone levels were measured and remained equivalent for both modes of therapy. Average penile growth response with gonadotropin was 14.3% increase in length and 5.0% increase of girth. Topical testosterone produced an average increase of 60% in penile length and 52.9% in girth. The greatest growth response occurred in prepubertal male subjects with a minimal response in postpubertal male subjects. This study suggests that 10% topical testosterone cream twice daily will produce effective penile growth. The response appears to be greater in younger children, which is consistent with previously published studies of age-related 5 reductase activity.
五名患有与下丘脑性性腺功能减退相关的小阴茎患者接受了促性腺激素和外用睾酮治疗。所有患者每周接受1000单位促性腺激素治疗，共3周，间隔6周后，每天两次外用10%睾酮乳膏，持续3周。测量了血清睾酮水平，两种治疗方式下该水平保持相当。使用促性腺激素时阴茎平均生长反应为长度增加14.3%，周长增加5.0%。外用睾酮使阴茎长度平均增加60%，周长增加52.9%。最大的生长反应出现在青春期前男性受试者中，青春期后男性受试者的反应最小。这项研究表明，每天两次外用10%睾酮乳膏将产生有效的阴茎生长。这种反应在年幼儿童中似乎更大，这与先前发表的关于年龄相关的5还原酶活性的研究一致。
