Ortbals D W, Marks E S, Liebhaber H
JAMA. 1978 Jun 16;239(24):2562-5. doi: 10.1001/jama.239.24.2562.
Patients receiving long-term hemodialysis (23) and patients with moderate to severe renal impairment and without hemodialysis (14) were immunized with inactivated influenza A/New Jersey/76 whole virus vaccine. Fourfold or greater increases in hemagglutinating-inhibiting antibody (HAI) titers occurred in 94% of controls, 93% of nondialyzed patients with chronic renal disease, and 87% of patients with continual hemodialysis. Postimmunization geometric mean titers in both groups of patients were equivalent to those of controls. The proportion of patients responding to vaccine was independent of levels of creatinine clearance, and the presence of preimmunization HAI titers also had no effect on frequency of seroconversion. Though some element of immunologic suppression is associated with chronic renal disease, it is not reflected in the humoral antibody response to influenza A/New Jersey/76 vaccine.
接受长期血液透析的患者（23例）以及患有中度至重度肾功能损害且未进行血液透析的患者（14例）接种了甲型流感/新泽西/76全病毒灭活疫苗。94%的对照组、93%的非透析慢性肾病患者以及87%的持续血液透析患者的血凝抑制抗体（HAI）滴度出现了四倍或更高的升高。两组患者免疫后的几何平均滴度与对照组相当。对疫苗有反应的患者比例与肌酐清除率水平无关，免疫前HAI滴度的存在对血清转化频率也没有影响。虽然慢性肾病与某种免疫抑制因素有关，但在对甲型流感/新泽西/76疫苗的体液抗体反应中并未体现出来。
