Nonomura A, Matsubara F, Nakamura Y, Kawashima Y, Hirone T, Ohta G
Acta Pathol Jpn. 1983 Nov;33(6):1289-301. doi: 10.1111/j.1440-1827.1983.tb02174.x.
A male, 53 years old, complained of a mass on the left side of neck. The biopsy specimens revealed extensive necrotizing lesions with polymorphonuclear leukocyte infiltration. About three years later a recurrence from the same site was noted and the rebiopsy specimens showed features of malignant lymphoma of pleomorphic type. Subsequently multiple cutaneous nodules and then ulcerative lesions of the midfacial region developed and repeated biopsies were done. Immunological examination indicated that the lymphoid cells obtained from the skin lesion had predominantly T-lymphocyte marker. He died of massive hemorrhage from the nasopharyngeal lesion 51 months after the first admission. Autopsy revealed multiple organ involvements, including the nasopharynx, lungs, subcutaneous tissue, and adrenal gland. The morphological features in the present case were compatible with a diagnosis of lymphomatoid granulomatosis or polymorphic reticulosis (midline malignant reticulosis), and were thought to be best designated as T cell lymphoma.
一名53岁男性，主诉颈部左侧有一肿块。活检标本显示广泛的坏死性病变伴多形核白细胞浸润。大约三年后，发现同一部位复发，再次活检标本显示为多形性恶性淋巴瘤特征。随后，面部中部出现多个皮肤结节，接着出现溃疡性病变，并进行了多次活检。免疫检查表明，从皮肤病变处获取的淋巴细胞主要具有T淋巴细胞标志物。首次入院51个月后，他死于鼻咽部病变大出血。尸检发现多个器官受累，包括鼻咽部、肺部、皮下组织和肾上腺。本例的形态学特征符合淋巴瘤样肉芽肿病或多形性网状细胞增多症（中线恶性网状细胞增多症）的诊断，被认为最宜诊断为T细胞淋巴瘤。
