Valdiserri R O, Petronie J S
Am J Clin Pathol. 1984 Mar;81(3):308-11. doi: 10.1093/ajcp/81.3.308.
A comparative evaluation of two commercial kits that detect antinuclear antibodies via indirect immunofluorescence was undertaken using an adult ambulatory population. The sensitivity and specificity of the kits were compared to determine which of the two was more efficient as a screening test for systemic lupus erythematosus specifically and connective tissue disease in general. Both were equally efficient. The authors emphasize the importance of accurate clinical information in verifying health/disease status when attempting to compare the efficacy of laboratory tests, especially screening procedures. Also important is a valid assessment of the number of false positives likely to be present in the test population, and this is best determined through prospective evaluation.
使用成年门诊人群对两种通过间接免疫荧光检测抗核抗体的商业试剂盒进行了比较评估。比较了这两种试剂盒的敏感性和特异性，以确定哪一种作为系统性红斑狼疮及一般结缔组织病的筛查试验更有效。两者效率相当。作者强调，在试图比较实验室检测（尤其是筛查程序）的疗效时，准确的临床信息对于核实健康/疾病状况的重要性。同样重要的是对测试人群中可能出现的假阳性数量进行有效评估，而这最好通过前瞻性评估来确定。
