Huber C, Fuchs D, Niederwieser D, Hausen A, Reibnegger G, Nilsson K, Wachter H
Klin Wochenschr. 1984 Feb 1;62(3):103-13. doi: 10.1007/BF01738700.
Activated T-lymphocytes represent crucial effector cells. They are pathogenetically involved into various disease states such as allograft rejection or viral infection. So far their assessment is laborious and rarely possible in clinical routine. In this review article we present the compount neopterin as a new biochemical marker for the in vivo and in vitro detection of activated T-lymphocytes. Our main finding was that in vitro as well as in vivo stimulation of T-lymphocytes with foreign and chemically or virally modified autologous cells in invariably associated with increased neopterin production. It thus appeared that neopterin might represent a potential marker for biochemical monitoring of diseases caused by or associated with T-lymphocyte activation. Our clinical experience with neopterin determination in allograft rejection and in infectious or autoimmune states strongly support this view. We conclude that evaluation of neopterin represents a useful and simple tool for the biochemical monitoring of immunological and/or malignant states.
活化的T淋巴细胞是关键的效应细胞。它们在发病机制上参与多种疾病状态，如同种异体移植排斥反应或病毒感染。到目前为止，对它们的评估费力且在临床常规中很少可行。在这篇综述文章中，我们介绍了化合物新蝶呤作为体内和体外检测活化T淋巴细胞的一种新的生化标志物。我们的主要发现是，用外来的以及化学或病毒修饰的自体细胞在体外和体内刺激T淋巴细胞，总是伴随着新蝶呤产生增加。因此，新蝶呤似乎可能是由T淋巴细胞活化引起或与之相关的疾病生化监测的一个潜在标志物。我们在同种异体移植排斥反应以及感染或自身免疫状态下测定新蝶呤的临床经验有力地支持了这一观点。我们得出结论，新蝶呤评估是免疫和/或恶性状态生化监测的一个有用且简单的工具。
