Zech L, Gahrton G, Hammarström L, Juliusson G, Mellstedt H, Robèrt K H, Smith C I
Nature. 1984;308(5962):858-60. doi: 10.1038/308858a0.
Rare cases of chronic lymphocytic leukaemia (CLL) in man stem from the malignant proliferation of T cells. The disease is usually more aggressive clinically than B-cell-derived CLL. Various haematological tumours are associated with specific chromosome aberrations (for example, refs 1, 2). Only limited numbers of T-cell CLL patients have so far been studied cytogenetically and, whereas chromosome 12 seems particularly to be involved in B-cell CLL, several markers have been found in T-cell tumours. Recently, by stimulating malignant clones with different mitogens, novel chromosome abnormalities have been detected in T-cell CLL. Using the same approach for additional cases of T-cell CLL, we now report that the most consistent chromosome change is an inversion of the long arm of chromosome 14, inv(14)(q11 q32), in four of five patients. Another remarkable chromosome aberration is trisomy for the long arm of chromosome 8, found in three of five patients.
人类慢性淋巴细胞白血病（CLL）的罕见病例源于T细胞的恶性增殖。该疾病在临床上通常比B细胞来源的CLL更具侵袭性。各种血液肿瘤与特定的染色体畸变相关（例如，参考文献1、2）。到目前为止，仅对有限数量的T细胞CLL患者进行了细胞遗传学研究，虽然12号染色体似乎特别与B细胞CLL有关，但在T细胞肿瘤中也发现了几种标记物。最近，通过用不同的有丝分裂原刺激恶性克隆，在T细胞CLL中检测到了新的染色体异常。对更多的T细胞CLL病例采用相同的方法，我们现在报告，在五名患者中的四名患者中，最一致的染色体变化是14号染色体长臂倒位，inv(14)(q11 q32)。另一个显著的染色体畸变是8号染色体长臂三体，在五名患者中的三名患者中发现。
