Gossop M, Bradley B
Drug Alcohol Depend. 1984 Mar;13(2):191-8. doi: 10.1016/0376-8716(84)90058-9.
Measures of sleep disturbance were taken among drug-dependent inpatients being withdrawn from opiates using either a conventional oral methadone regime or electrostimulation (ES). Sleep was found to be disturbed in both groups. Subjects receiving ES showed the more marked sleep reduction and higher levels of night time waking during withdrawal: insomnia was most evident during the first 14 days of withdrawal. The degree of sleep disturbance among the methadone subjects was less severe but there were also sleep difficulties in this group. As late as 1 month after admission there was considerable night-to-night variability in sleep times with mean values between 4 h and 6 h in both groups. The ES procedure was unsatisfactory for managing insomnia during opiate withdrawal, but neither can methadone be regarded as fully satisfactory in this respect. An incidental finding to emerge from this study is that those subjects in the ES group who remained in treatment experienced more sleep disturbance than those who dropped out prematurely.
对正在使用传统口服美沙酮疗法或电刺激（ES）进行阿片类药物戒断的药物依赖住院患者进行了睡眠障碍测量。发现两组患者的睡眠均受到干扰。接受电刺激的受试者在戒断期间睡眠减少更为明显，夜间觉醒水平更高：失眠在戒断的前14天最为明显。美沙酮组的睡眠障碍程度较轻，但该组也存在睡眠困难。入院后1个月时，两组的睡眠时间仍存在相当大的夜间波动，平均值在4小时至6小时之间。电刺激程序在阿片类药物戒断期间治疗失眠并不理想，但在这方面美沙酮也不能被视为完全令人满意。这项研究中出现的一个偶然发现是，ES组中继续接受治疗的受试者比过早退出治疗的受试者经历了更多的睡眠障碍。
