Cox D S, Muench D
Int Arch Allergy Appl Immunol. 1984;74(3):249-55. doi: 10.1159/000233553.
The effect of the introduction of antigen by gastric intubation on the locally stimulated mammary gland IgA antibody (Ab) response was examined. Rats receiving a particulate DNP antigen by gastric intubation prior to injection in the vicinity of the mammary glands ( MGV ) demonstrated increased levels of IgA Ab in milk. Soluble DNP antigen introduction by gastric intubation did not lead to increased IgA Ab levels in milk. Prior administration of either form of DNP antigen by gastric intubation did not affect the IgG response. Only those rats receiving particulate DNP antigen by intubation demonstrated salivary IgA Ab. Particulate forms of antigen administered by intubation can provide a means of increasing the locally induced IgA response at a secretory site.
研究了通过胃插管引入抗原对局部刺激的乳腺IgA抗体（Ab）反应的影响。在乳腺附近（MGV）注射之前通过胃插管接受颗粒状DNP抗原的大鼠，其乳汁中的IgA Ab水平升高。通过胃插管引入可溶性DNP抗原并未导致乳汁中IgA Ab水平升高。通过胃插管预先给予任何一种形式的DNP抗原均不影响IgG反应。只有那些通过插管接受颗粒状DNP抗原的大鼠表现出唾液IgA Ab。通过插管给予的颗粒状抗原形式可以提供一种增加分泌部位局部诱导的IgA反应的方法。
