表皮生长因子刺激经体外灌流的大鼠腺垂体碎片分泌生长激素。
Epidermal growth factor stimulates growth hormone secretion from superfused rat adenohypophyseal fragments.
作者信息
Ikeda H, Mitsuhashi T, Kubota K, Kuzuya N, Uchimura H
出版信息
Endocrinology. 1984 Aug;115(2):556-8. doi: 10.1210/endo-115-2-556.
PMID:6611253
Abstract
Epidermal growth factor (EGF) stimulated GH secretion from superfused rat adenohypophyseal fragments in a dose-related manner (8-50 ng/ml). Secretion of PRL or TSH was not affected by EGF at concentrations up to 50 ng/ml. These results indicate that EGF may be a specific secretagogue for GH in rats.
摘要
表皮生长因子（EGF）以剂量相关方式（8 - 50 ng/ml）刺激大鼠垂体前叶碎片灌流液中的生长激素（GH）分泌。在浓度高达50 ng/ml时，EGF对催乳素（PRL）或促甲状腺激素（TSH）的分泌没有影响。这些结果表明，EGF可能是大鼠生长激素的一种特异性促分泌素。
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