人/小鼠和人/中国仓鼠杂交细胞上HLA、β2-微球蛋白及狨猴红细胞受体的表达与关系

The expression and relation of HLA, beta2-microglobulin and receptor for marmoset red blood cells on man/mouse and man/Chinese hamster hybrid cells.

作者信息

Fellous M, Hors M C, Rebourcet R, Finaz C, Weil D, Heuertz S, Wiels J, Mahouy G, Fridman W H

出版信息

Eur J Immunol. 1977 Jan;7(1):22-6. doi: 10.1002/eji.1830070106.

Abstract

The expression of HLA, human and mouse beta2-microglobulin (beta2m), P red blood cell antigen and a receptor for marmoset red blood cells (MaRBC) were studied on 18 man/mouse and man/Chinese hamster hybrids. A positive correlation was found between the expression of HLA, P, and the receptor for MaRBC, which we interpret as a possible synteny between these different loci. We studied 3 hybrid clones where HLA antigens are still expressed despite the absence of human beta2m and where redistribution experiments demonstrate that HLA is associated with mouse beta2m. Synteny between HLA and the receptor for MaRBC can be a useful tool to select HLA-positive hybrid clones.

摘要

在18个人/小鼠和人/中国仓鼠杂种中研究了HLA、人及小鼠β2-微球蛋白（β2m）、P红细胞抗原和狨猴红细胞（MaRBC）受体的表达。发现HLA、P和MaRBC受体的表达之间存在正相关，我们将其解释为这些不同基因座之间可能存在同线性。我们研究了3个杂种克隆，尽管不存在人β2m，但仍表达HLA抗原，并且重新分布实验表明HLA与小鼠β2m相关。HLA和MaRBC受体之间的同线性可能是选择HLA阳性杂种克隆的有用工具。