Goodbody A E, Trayhurn P
Biochem J. 1981 Mar 15;194(3):1019-22. doi: 10.1042/bj1941019.
GDP binding to brown-adipose-tissue mitochondria from adult diabetic--obese (db/db) mice was significantly less than with lean siblings. Binding was also decreased in the mutant mice before obesity had begun to develop. Decreased GDP binding was found to result from a decrease in the number of binding sites.
成年糖尿病肥胖(db/db)小鼠棕色脂肪组织线粒体中GDP的结合量显著低于其瘦的同胞小鼠。在肥胖开始发展之前,突变小鼠中的结合也有所减少。发现GDP结合减少是由于结合位点数量减少所致。