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GDP与糖尿病肥胖(db/db)小鼠棕色脂肪组织线粒体的结合。在肥胖和肥胖前期状态下结合均减少。

GDP binding to brown-adipose-tissue mitochondria of diabetic--obese (db/db) mice. Decreased binding in both the obese and pre-obese states.

作者信息

Goodbody A E, Trayhurn P

出版信息

Biochem J. 1981 Mar 15;194(3):1019-22. doi: 10.1042/bj1941019.

Abstract

GDP binding to brown-adipose-tissue mitochondria from adult diabetic--obese (db/db) mice was significantly less than with lean siblings. Binding was also decreased in the mutant mice before obesity had begun to develop. Decreased GDP binding was found to result from a decrease in the number of binding sites.

摘要

成年糖尿病肥胖(db/db)小鼠棕色脂肪组织线粒体中GDP的结合量显著低于其瘦的同胞小鼠。在肥胖开始发展之前,突变小鼠中的结合也有所减少。发现GDP结合减少是由于结合位点数量减少所致。

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本文引用的文献

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Thermogenic defect in pre-obese ob/ob mice.肥胖前期ob/ob小鼠的产热缺陷
Nature. 1977 Mar 3;266(5597):60-2. doi: 10.1038/266060a0.

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