Buc H A, Augereau C, Demaugre F, Moncion A, Leroux J P
Biochim Biophys Acta. 1983 Sep 22;763(2):220-3. doi: 10.1016/0167-4889(83)90048-4.
In hepatocytes isolated from fed rats, physiological concentrations of oxalate lower the flux through the tricarboxylic acid cycle (-48%) and reduce the steady-state levels of oxaloacetate and other Krebs cycle intermediates. All the metabolic modifications observed are explained by pyruvate carboxylase inhibition, since oxalate hardly modifies the flux through pyruvate dehydrogenase.
在从喂食后的大鼠分离出的肝细胞中，生理浓度的草酸盐会降低三羧酸循环的通量（降低48%），并降低草酰乙酸和其他三羧酸循环中间产物的稳态水平。观察到的所有代谢变化都可以通过丙酮酸羧化酶的抑制来解释，因为草酸盐几乎不会改变丙酮酸脱氢酶的通量。
