[Inhibition of lipid peroxidation by superoxide dismutase and ceruloplasmin].

Superoxide dismutase from erythrocytes and ceruloplasmin of serum inhibit the oxidation of phosphatidylcholine and phosphatidylethanolamine solubilized by cholate. Both enzymes also inhibit the oxidation of liposomes prepared from phosphatidylcholine. Ceruloplasmin as a lipid peroxidation inhibitor, is by two orders of magnitude less effective than superoxide dismutase. However, ceruloplasmin can be considered as the main antioxidant system of serum because its concentration in the serum is high. An inclusion of ceruloplasmin and superoxide dismutase into the inner volume of liposomes was achieved. It was shown that the substrate of ceruloplasmin, N,N,N',N'-tetramethyl-p-phenylenediamine, does not penetrate across the liposomal membranes.