Fredrikzon B, Olivecrona T
Pediatr Res. 1978 May;12(5):631-4. doi: 10.1203/00006450-197805000-00004.
Both lipase and esterase activities were present in intestinal contents of all newborns studied, from the first day of life. In adults given a test meal lipase activity increased and esterase activity remained unchanged. In contrast, both activities decreased markedly in infants on feeding. During the digestion of the test meal the lipase activity in intestinal contents of the infants was much lower than in adults (ratio of median values 1:27) and the esterase activity was also several fold lower (ratio of median values 1:1.3). Speculation Newborn infants often absorb lipids less efficiently than adults. One contributing factor may be that their incompletely developed pancreas responds to feedings with comparatively low outputs of lipolytic enzymes. The newborn may be more dependent than adults on auxiliary sources of lipase activity such as the pharyngeal lipase and/or the bile-stimulated lipase in human milk.
从出生第一天起，所有接受研究的新生儿的肠内容物中都存在脂肪酶和酯酶活性。给予试验餐的成年人，其脂肪酶活性增加，酯酶活性保持不变。相比之下，喂食的婴儿这两种活性均显著下降。在试验餐消化过程中，婴儿肠内容物中的脂肪酶活性远低于成年人（中位数比值为1:27），酯酶活性也低几倍（中位数比值为1:1.3）。推测新生儿吸收脂质的效率通常低于成年人。一个促成因素可能是他们发育不完全的胰腺对喂食的反应是脂解酶输出相对较低。新生儿可能比成年人更依赖脂肪酶活性的辅助来源，如人乳中的咽脂肪酶和/或胆汁刺激脂肪酶。
