Brown B, Kitchin J L
Am J Optom Physiol Opt. 1983 Aug;60(8):645-50. doi: 10.1097/00006324-198308000-00001.
Patients with senile macular degeneration (SMD) often complain of problems with adaptation and have best acuity under a restricted range of lighting conditions. We investigated dark adaptation and acuity over a wide range of luminances in eight SMD patients and six age-matched controls. Some patients showed evidence of altered dark adaptation, with a much longer time required to reach asymptotic sensitivity levels than shown by normals; others had difficulty with spatial resolution at different light levels. There was good correlation between symptoms and test findings; all but one patient who reported difficulties with adaptation demonstrated either retarded adaptation, aberrant acuity/luminance response, or both. These data provide evidence that the processes which adjust the sensitivity of the retina and the spatial summation properties of the retina are disrupted in SMD.
老年性黄斑变性（SMD）患者常抱怨适应方面的问题，并且在有限的光照条件范围内视力最佳。我们研究了8名SMD患者和6名年龄匹配的对照者在广泛亮度范围内的暗适应和视力情况。一些患者表现出暗适应改变的迹象，达到渐近敏感水平所需的时间比正常人长得多；另一些患者在不同光照水平下的空间分辨率存在困难。症状与测试结果之间有良好的相关性；除一名报告适应困难的患者外，所有报告适应困难的患者均表现出适应延迟、异常的视力/亮度反应或两者皆有。这些数据表明，在SMD中，调节视网膜敏感性和视网膜空间总和特性的过程受到了干扰。
