Brown B, Garner L F
Am J Optom Physiol Opt. 1983 Sep;60(9):788-93. doi: 10.1097/00006324-198309000-00008.
Patients with senile macular degeneration (SMD) often have difficulties in adapting to changing luminance levels. They may complain of problems at both high and low luminance levels, although some patients have their vision function markedly improved at high luminance levels. We examined the effect of luminance on the contrast sensitivity function in six patients with SMD and five normals of approximately the same age. The contrast sensitivity of the SMD patients compared to the control subjects was reduced at 72 cd/m2 but was comparable to that of the controls at 0.007 cd/m2. The peak of the contrast sensitivity function was moved to lower spatial frequencies at all luminances in the SMD group, and the slope of the function relating contrast sensitivity to luminance was reduced. These data suggest that adaptation mechanisms which optimize contrast detection are disrupted in SMD. Further disturbances of function might be expected in the dynamics of the adaptation process.
老年性黄斑变性（SMD）患者在适应亮度变化水平时常常存在困难。他们可能会抱怨在高亮度和低亮度水平下都有问题，尽管有些患者在高亮度水平下视觉功能有明显改善。我们研究了亮度对6例SMD患者和5例年龄相近的正常人对比敏感度函数的影响。与对照组相比，SMD患者在72 cd/m² 时对比敏感度降低，但在0.007 cd/m² 时与对照组相当。SMD组在所有亮度下对比敏感度函数的峰值都向较低空间频率移动，且对比敏感度与亮度关系函数的斜率降低。这些数据表明，在SMD中，优化对比度检测的适应机制受到破坏。在适应过程的动态变化中，可能还会出现进一步的功能障碍。
