McNaughton B L, Barnes C A, O'Keefe J
Exp Brain Res. 1983;52(1):41-9. doi: 10.1007/BF00237147.
Isolated single units in rat dorsal hippocampus and fascia dentata were classified as 'Theta' or 'Complex-Spike' cells, and their firing characteristics were examined with respect to position, direction and velocity of movement during forced choice, food rewarded search behavior on a radial eight arm maze. Most spikes from CS cells occurred when the animal was located within a particular place on the maze and moving in a particular direction. Theta cells had very low spatial selectivity. Both cell categories had discharge probabilities which increased somewhat as a function of running velocity but tended to asymptote well before half-maximal velocity. The place/direction specificity of CS cells was significantly higher in CA1 than in CA3 and CA3 CS cells exhibited a striking preference for the inward radial direction. The pronounced directional selectivity of CS cells, at least in the present environment, suggests that they fire in response to complex, but specific, stimulus features in the extramaze world rather than to absolute place in a non-egocentric space. An alternative possibility is that the geometrical constraints of the maze surface have a profound influence on the shapes of the response fields of CS cells.
在大鼠背侧海马体和齿状回中分离出的单个神经元被分类为“θ”细胞或“复合锋电位”细胞，并在径向八臂迷宫中进行强制选择、食物奖励搜索行为期间，针对动物运动的位置、方向和速度，研究了它们的放电特性。“复合锋电位”细胞的大多数锋电位出现在动物位于迷宫上特定位置并沿特定方向移动时。θ细胞的空间选择性非常低。这两类细胞的放电概率均随奔跑速度的增加而有所增加，但在速度达到最大速度的一半之前就趋于平稳。“复合锋电位”细胞在CA1区的位置/方向特异性明显高于CA3区，且CA3区的“复合锋电位”细胞对内径向方向表现出明显的偏好。至少在当前环境中，“复合锋电位”细胞明显的方向选择性表明，它们是对外界复杂但特定的刺激特征做出反应而放电，而非对非自我中心空间中的绝对位置做出反应。另一种可能性是，迷宫表面的几何约束对“复合锋电位”细胞反应场的形状有深远影响。
