Le Gal La Salle G, Feldblum S
Exp Neurol. 1983 Nov;82(2):447-55. doi: 10.1016/0014-4886(83)90416-8.
The influence that the amygdala may exert on the development of hippocampal kindling was investigated using three different approaches: (i) after uni- or bilateral amygdalectomy by thermocoagulation, (ii) after prestimulation of the amygdala until the appearance of masticatory movements, and (iii) after increasing the GABA concentration in the amygdala with gamma-vinyl GABA. Hippocampal kindling was not significantly modified in amygdalectomized animals. On the contrary, prestimulation of the ipsilateral amygdala facilitated the subsequent hippocampal kindling. Finally, microinjection of gamma-vinyl GABA in both amygdalae either reduced the seizures to a prekindled level or strongly delayed the appearance of the motor signs of kindling. It is suggested that hippocampal kindling may develop preferentially through the amygdala.
(i) 通过热凝进行单侧或双侧杏仁核切除术后；(ii) 在对杏仁核进行预刺激直至出现咀嚼运动后；(iii) 在杏仁核中用γ-乙烯基 GABA 增加 GABA 浓度后。在杏仁核切除的动物中，海马点燃没有显著改变。相反，同侧杏仁核的预刺激促进了随后的海马点燃。最后，在双侧杏仁核中微量注射γ-乙烯基 GABA 要么将癫痫发作减少到预点燃水平，要么强烈延迟点燃运动体征的出现。提示海马点燃可能优先通过杏仁核发展。
