N-丁基-N-(4-羟基丁基)亚硝胺诱导的具有细胞镶嵌性的小鼠膀胱癌的单细胞起源
Single-cell origin of bladder cancer induced by N-butyl-N-(4-hydroxybutyl) nitrosamine in mice with cellular mosaicism.
作者信息
Kakizoe T, Tanooka H, Tanaka K, Sugimura T
出版信息
Gan. 1983 Aug;74(4):462-5.
PMID:6628898
Abstract
The single-cell origin of bladder cancer was established in mice with cellular mosaicism for phosphoglycerate kinase (PGK). Administration of N-butyl-N-(4-hydroxybutyl)nitrosamine in the drinking water resulted in development of large, solitary, infiltrating bladder carcinomas. On electrophoresis, PGK from all the cancer tissues examined gave only a single spot.
摘要
通过对磷酸甘油酸激酶（PGK）进行细胞镶嵌的小鼠，证实了膀胱癌的单细胞起源。在饮用水中给予N-丁基-N-（4-羟基丁基）亚硝胺会导致大型、孤立性、浸润性膀胱癌的发生。电泳结果显示，所有检测的癌组织中的PGK仅出现一个条带。
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