用于监测卵巢癌患者的生化辅助手段。

Biochemical aids in the monitoring of patients with ovarian cancer.

作者信息

Meerwaldt J H, Haije W G, Cooper E H, Pidcock N B, v d Burg M E

出版信息

Gynecol Oncol. 1983 Oct;16(2):209-18. doi: 10.1016/0090-8258(83)90095-1.

Abstract

A study of possible biochemical markers of tumor recurrence and progression was made in 93 patients with ovarian cancer followed longitudinally for up to 2 years during treatment by moderate or aggressive chemotherapy regimens. A panel of potential indicators was tested; the combination of serum albumin, C-reactive protein, alpha 1-acid glycoprotein, and phosphohexose isomerase levels was found to provide information that is useful as an adjunct to the clinical assessment of patients with advanced disease. However, the system could not detect a small tumor burden. The level of beta 2-microglobulin may have value in those patients whose tumor is associated with an increase of this analyte (77%), but it would appear to reflect a large tumor mass. Serum CEA, carcino-placental alkaline phosphatase, transferrin, and prealbumin were not found to be helpful.

摘要

对93例卵巢癌患者进行了一项关于肿瘤复发和进展的可能生化标志物的研究，这些患者在接受中度或积极化疗方案治疗期间进行了长达2年的纵向随访。对一组潜在指标进行了检测；发现血清白蛋白、C反应蛋白、α1-酸性糖蛋白和磷酸己糖异构酶水平的组合所提供的信息，可作为晚期疾病患者临床评估的辅助手段。然而，该系统无法检测到小肿瘤负荷。β2-微球蛋白水平在那些肿瘤与此分析物增加相关的患者中（77%）可能有价值，但它似乎反映的是大肿瘤块。未发现血清癌胚抗原、癌胎盘碱性磷酸酶、转铁蛋白和前白蛋白有帮助。