急性期反应蛋白谱：通过癌胚抗原和血清酶辅助监测大肠癌。
Acute-phase reactant protein profiles: an aid to monitoring large bowel cancer by CEA and serum enzymes.
作者信息
Ward A M, Cooper E H, Turner R, Anderson J A, Neville A M
出版信息
Br J Cancer. 1977 Feb;35(2):170-8. doi: 10.1038/bjc.1977.24.
Abstract
The profiles of 4 acute-phase reactant proteins (APRPs) (haptoglobin (HPT), alpha1 antitrypsin (AAT), alpha1 acid glycoprotein (AGP) and prealbumin (PALB)) have been studied during the evolution of bowel cancer. Serial measurements of these APRPs can add to the information obtained from measurements of the level of CEA and hepatic enzymes during the monitoring of postoperative patients. There is considerable stability in the profile in a given individual in health, Rises of AAT and AGP are associated with metastases. High levels of HPT may suggest involvement of the bowel wall by recurrent cancer. PALB levels tend to reflect the nutritional status. A discriminant function based on the log CEA, AAT and AGP preoperative blood levels can considerably improve on the predictive value attained using CEA levels alone.
摘要
在肠癌发展过程中，对4种急性期反应蛋白（APRP）（触珠蛋白（HPT）、α1抗胰蛋白酶（AAT）、α1酸性糖蛋白（AGP）和前白蛋白（PALB））的情况进行了研究。在对术后患者的监测过程中，对这些APRP进行系列测量可以补充从癌胚抗原（CEA）水平和肝酶测量中获得的信息。在健康个体中，给定个体的蛋白情况具有相当的稳定性，AAT和AGP升高与转移有关。高水平的HPT可能提示复发性癌症累及肠壁。PALB水平往往反映营养状况。基于术前血液中CEA、AAT和AGP的对数水平的判别函数可以显著提高仅使用CEA水平所获得的预测价值。
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