1976年汉福德钚暴露事件：二乙烯三胺五乙酸治疗期间痕量金属的尿排泄情况

1976 Hanford americium exposure incident: urinary excretion of trace metals during DTPA treatments.

作者信息

Kalkwarf D R, Thomas V W, Nielson K K, Mauch M L

出版信息

Health Phys. 1983 Oct;45(4):937-47. doi: 10.1097/00004032-198310000-00011.

DOI:10.1097/00004032-198310000-00011

Abstract

Urine samples from a person treated intravenously with diethyl-enetriaminepentaacetate (DTPA) salts for 3 yr to promote the excretion of 241Am were assayed for 24 elements including almost all of the trace metals currently recognized as essential for good health. Zinc was found to be the only metal excreted more rapidly than normal. An 18-mg urinary loss of body zinc was found to be associated with each 1-g injection of Na3CaDTPA. Use of either Na3ZnDTPA or Na3CaDTPA combined with oral dosages of ZnSO4 appeared to completely compensate for this loss, and it is unlikely that the patient experienced any zinc deficiency due to the DTPA treatment.

摘要

对一名静脉注射二乙三胺五乙酸（DTPA）盐3年以促进241Am排泄的患者的尿液样本进行了检测，分析了24种元素，包括几乎所有目前认为对身体健康至关重要的微量元素。发现锌是唯一排泄速度比正常情况更快的金属。每注射1克Na3CaDTPA，人体锌的尿流失量为18毫克。使用Na3ZnDTPA或Na3CaDTPA并结合口服硫酸锌似乎完全弥补了这种流失，该患者因DTPA治疗而出现锌缺乏的可能性不大。