Huovinen P, Pulkkinen L, Toivanen P
J Antimicrob Chemother. 1983 Sep;12(3):249-56. doi: 10.1093/jac/12.3.249.
Resistance to trimethoprim in urinary tract isolates was studied in the Turku City Hospital in 1979 and 1980-81 and in the Turku and Kuopio University Central Hospitals in 1980-81. In the Turku City Hospital no changes occurred during this time in the frequency of strains highly-resistant to trimethoprim (MIC greater than 1000 mg/l) or of those in which transferable resistance was demonstrated. However, the nature of resistance has changed since 1979, when the only transferable pattern was trimethoprim-ampicillin resistance. In 1980-81 over half of the transfer-positive stains transferred only trimethoprim resistance. In the university hospitals the strains highly-resistant to trimethoprim occurred in 36.8% of strains resistant to greater than or equal to 8 mg/l. This is significantly less than 68.7% observed at the same time in the Turku City Hospital. Among the highly-resistant strains the frequency of those transferring resistance was the same in the university hospitals as in the Turku City Hospital.
1979年以及1980 - 1981年期间，在图尔库市立医院对泌尿道分离菌株对甲氧苄啶的耐药性进行了研究，1980 - 1981年期间还在图尔库和库奥皮奥大学中心医院进行了研究。在图尔库市立医院，这段时间内对甲氧苄啶高度耐药（最低抑菌浓度大于1000毫克/升）的菌株频率或那些表现出可转移耐药性的菌株频率均未发生变化。然而，自1979年以来耐药性的性质发生了变化，当时唯一的可转移模式是甲氧苄啶 - 氨苄西林耐药。在1980 - 1981年，超过一半的转移阳性菌株仅转移甲氧苄啶耐药性。在大学医院中，对甲氧苄啶高度耐药的菌株出现在36.8%对大于或等于8毫克/升耐药的菌株中。这显著低于同期在图尔库市立医院观察到的68.7%。在高度耐药菌株中，大学医院中耐药性转移菌株的频率与图尔库市立医院相同。
