Huovinen P, Mäntyjärvi R, Toivanen P
Br Med J (Clin Res Ed). 1982 Mar 13;284(6318):782-4. doi: 10.1136/bmj.284.6318.782.
During November 1980 to April 1981, 1561 urinary tract pathogens were collected from Turku City Hospital, Turku University Central Hospital, and Kuopio University Central Hospital. Resistance of the strains was tested by agar-plate dilution against trimethoprim, sulphamethoxazole-trimethoprim, sulphamethoxazole, ampicillin, and nitrofurantoin. Resistance to trimethoprim (greater than 8 mg/l) occurred in 8.6-12.2% of strains from the university hospitals (Pseudomonas excluded) and 38.3% of strains from Turku City Hospital. Resistance of Escherichia coli occurred in 4.1-6.2% of strains from the university hospitals and 21% of strains from Turku City Hospital. Proteus mirabilis was the most resistant of the clinically important bacterial species with resistance to trimethoprim in 29-78%. Attention is called for in defining the type of hospital used for a particular study: bacterial resistance in different hospitals cannot be compared direct and one hospital is not necessarily representative for a whole country. After seven years' use of plain trimethoprim the prevalence of resistance in the two university hospitals in Finland was similar to that in a London hospital just before plain trimethoprim was registered for use in Britain.
1980年11月至1981年4月期间，从图尔库市立医院、图尔库大学中心医院和库奥皮奥大学中心医院收集了1561株尿路病原体。采用琼脂平板稀释法检测这些菌株对甲氧苄啶、复方新诺明、磺胺甲恶唑、氨苄西林和呋喃妥因的耐药性。大学医院（不包括铜绿假单胞菌）中8.6% - 12.2%的菌株对甲氧苄啶耐药（大于8mg/l），图尔库市立医院中38.3%的菌株耐药。大学医院中4.1% - 6.2%的大肠杆菌菌株耐药，图尔库市立医院中21%的菌株耐药。奇异变形杆菌是临床上重要的细菌种类中耐药性最强的，对甲氧苄啶的耐药率为29% - 78%。在确定用于特定研究的医院类型时需要注意：不同医院的细菌耐药性不能直接比较，一家医院不一定能代表整个国家。在单纯使用甲氧苄啶七年之后，芬兰两家大学医院的耐药率与英国即将注册使用单纯甲氧苄啶之前伦敦一家医院的耐药率相似。
