Saranto J R, Rubayi S, Zawacki B E
J Trauma. 1983 Oct;23(10):927-33. doi: 10.1097/00005373-198310000-00015.
To appraise the ability of each to improve wound healing in zone-of-stasis burns (i.e., burns becoming progressively more ischemic early postburn), 1) an antithromboxane (dipyridamol PO immediately postburn), 2) burn-wound cooling, 3) their combination, or 4) no treatment was administered to burned guinea pigs half of which had burn blisters removed immediately postburn (PB). In all groups with blisters removed whole-thickness or very deep partial-thickness skin loss occurred. In all groups with blisters intact complete reversal of ischemia occurred without necrosis and, while dipyridamol and cooling each diminished stasis early PB, only cooled wounds showed any improved retention of hair follicles at 3 weeks PB. In this model, therefore: 1) blister removal eliminated any therapeutic effect of cooling or dipyridamol; 2) in burns with blisters intact, absorbed heat appeared at least as detrimental to healing as stasis, and 3) some of the beneficial effects of cooling appeared unrelated to prevention of stasis.
为评估每种方法促进淤滞区烧伤（即烧伤后早期缺血情况逐渐加重的烧伤）伤口愈合的能力，对烧伤的豚鼠进行了如下处理：1）给予抗血栓素（烧伤后立即口服双嘧达莫），2）对烧伤创面进行降温，3）联合使用上述两种方法，4）不进行任何处理。其中一半豚鼠在烧伤后立即去除烧伤水疱（PB）。在所有去除水疱的组中，均出现了全层或极深的部分厚度皮肤缺损。在所有水疱完整的组中，缺血完全逆转，未发生坏死，虽然双嘧达莫和降温在烧伤后早期均减轻了淤滞，但只有降温处理的伤口在烧伤后3周时毛囊保留情况有所改善。因此，在该模型中：1）去除水疱消除了降温或双嘧达莫的任何治疗效果；2）在水疱完整的烧伤中，吸收的热量对愈合的损害似乎至少与淤滞一样大；3）降温的一些有益效果似乎与预防淤滞无关。
