苯环利定可降低大鼠纹状体中甲硫氨酸脑啡肽的含量。

Phencyclidine decreases methionine-enkephalin content in rat striatum.

作者信息

Fratta W, Zivcovic B, Gessa G L

出版信息

Neurosci Lett. 1983 Aug 29;39(2):161-3. doi: 10.1016/0304-3940(83)90070-8.

Abstract

The acute administration of phencyclidine induced a decrease in methionine-enkephalin levels in rat striatum, as measured by specific radioimmunoassay. The maximum decrease (about 40% with respect to controls) was obtained at a dose of 20 mg/kg, 30 min after intraperitoneal injection. These results suggest a possible involvement of enkephalins in the central effects of phencyclidine.

摘要

通过特定放射免疫测定法测得，给大鼠急性注射苯环己哌啶会导致其纹状体中甲硫氨酸脑啡肽水平降低。腹腔注射后30分钟，剂量为20毫克/千克时出现最大降幅（相对于对照组约为40%）。这些结果表明脑啡肽可能参与了苯环己哌啶的中枢效应。