苯环利定导致小鼠大脑中甲硫氨酸脑啡肽水平降低。
Phencyclidine-induced decrease of methionine-enkephalin levels in mouse brain.
作者信息
Nabeshima T, Hiramatsu M, Amano M, Furukawa H, Kameyama T
出版信息
Eur J Pharmacol. 1982 Dec 24;86(2):271-3. doi: 10.1016/0014-2999(82)90325-9.
The effects of acute administration of phencyclidine (PCP) on the steady state levels of methionine-enkephalin in discrete brain areas were investigated in mice. The methionine-enkephalin levels in the medulla oblongata-pons and the midbrain were decreased by the administration of PCP. However, PCP induced no change of the methionine-enkephalin levels in other brain areas at the dose range of 5-20 mg/kg. These results suggest that the pharmacological effects of PCP may involve changes in enkephalinergic neuronal activity.
研究了给小鼠急性注射苯环利定（PCP）对离散脑区中甲硫氨酸脑啡肽稳态水平的影响。注射PCP后，延髓-脑桥和中脑中的甲硫氨酸脑啡肽水平降低。然而，在5-20mg/kg的剂量范围内，PCP并未引起其他脑区中甲硫氨酸脑啡肽水平的变化。这些结果表明，PCP的药理作用可能涉及脑啡肽能神经元活动的改变。
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