内侧视前区-下丘脑前部损伤对雄性大鼠血浆睾酮水平及下丘脑睾酮转化的影响。
The effect of medial preoptic-anterior hypothalamic lesions on testosterone plasma levels and testosterone conversion in the hypothalamus of male rats.
作者信息
Lupo C, Dessi-Fulgheri F, Musi B, Larsson K
出版信息
Neurosci Lett. 1983 Sep 9;39(3):261-5. doi: 10.1016/0304-3940(83)90310-5.
Male Wistar rats were submitted to bilateral high frequency lesions in the medial preoptic-anterior hypothalamic area or to sham procedure. The behavioral effect of the lesions was observed and plasma testosterone (T) and estradiol (E2) were measured by radioimmunoassay. In vitro metabolism of T was studied in the hypothalamus. Lesions produced a permanent deficit in male sexual behavior, an increase of plasma T and E2, and of hypothalamic T aromatization, and a decrease of T conversion to 5 alpha-dihydrotestosterone (DHT).
将雄性Wistar大鼠的内侧视前区-下丘脑前部区域进行双侧高频损伤，或进行假手术。观察损伤的行为效应，并通过放射免疫测定法测量血浆睾酮（T）和雌二醇（E2）。研究下丘脑T的体外代谢。损伤导致雄性性行为永久性缺陷、血浆T和E2增加、下丘脑T芳香化增加，以及T向5α-双氢睾酮（DHT）的转化减少。
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