Martin D E, Glick B
Poult Sci. 1983 Sep;62(9):1856-9. doi: 10.3382/ps.0621856.
Avian lymphocyte inhibitory factor (LyIF) is produced by thymic (T) and bursal (B) lymphocytes following sensitization of chicks to Mycobacterium tuberculosis. Our previous studies showed that maximum activities for both B- and T-LyIF were within a molecular weight range of 10,000 to 50,000 daltons (LyIF-III). These results led us to question what other functional differences may exist. The chemotactic and mitogenic properties of B- and T-LyIF-III were investigated. Neither B- nor T-LyIF-III had chemotactic properties whereas both lymphokines significantly inhibited the uptake of [3H]-thymidine in the presence of phytohemagglutinin-M. Inhibition of migration by LyIF-III may be a reflection of LyIF-III inhibition of deoxyribonucleic acid synthesis.
禽淋巴细胞抑制因子（LyIF）是雏鸡对结核分枝杆菌致敏后由胸腺（T）淋巴细胞和法氏囊（B）淋巴细胞产生的。我们之前的研究表明，B-LyIF和T-LyIF的最大活性都在分子量10,000至50,000道尔顿范围内（LyIF-III）。这些结果促使我们去探究可能还存在哪些其他功能差异。我们研究了B-LyIF-III和T-LyIF-III的趋化性和促有丝分裂特性。B-LyIF-III和T-LyIF-III均无趋化特性，而这两种淋巴细胞因子在存在植物血凝素-M的情况下均能显著抑制[3H] - 胸腺嘧啶核苷的摄取。LyIF-III对迁移的抑制可能反映了LyIF-III对脱氧核糖核酸合成的抑制作用。
