Wolaniuk A, Vadhanavikit S, Folkers K
Res Commun Chem Pathol Pharmacol. 1983 Sep;41(3):501-11.
Six typical patients with the carpal tunnel syndrome in a neurological practice were double blindly treated with pyridoxine and placebo to determine whether electromyographic data alone could identify without mistake those patients receiving pyridoxine or placebo. All six patients had a significant deficiency of vitamin B6 by the data on the erythrocyte glutamic oxaloacetic transaminase. Multiple measurements for statistical significance of EMG functions were made on temperature-controlled hands over periods of 15 to 27 days for control and final evaluation. There were significant changes in criteria of amplitude on placebo which ruled out these criteria for a double blind trial. There was no statistically significant change in any criterion of latency and conduction velocity for patients on placebo, indicating these criteria could serve for differentiation. Criteria of latency and conduction velocity showed significant changes for three patients on pyridoxine, and the extent of changes indicated a relationship to compliance. By data on latency and conduction velocity, no mistake was made in blindly identifying patients receiving pyridoxine or placebo; p less than 0.0156.
在一家神经科诊所，对6名典型的腕管综合征患者进行了吡哆醇和安慰剂的双盲治疗，以确定仅靠肌电图数据能否无误地识别出接受吡哆醇或安慰剂治疗的患者。根据红细胞谷草转氨酶的数据，所有6名患者都存在明显的维生素B6缺乏。在温度控制的手上，对肌电图功能进行了多次测量，测量时间为15至27天，用于对照和最终评估。安慰剂组的振幅标准有显著变化，这排除了这些标准用于双盲试验的可能性。安慰剂组患者的潜伏期和传导速度的任何标准均无统计学上的显著变化，表明这些标准可用于区分。接受吡哆醇治疗的3名患者的潜伏期和传导速度标准有显著变化，变化程度表明与依从性有关。根据潜伏期和传导速度的数据，在盲目识别接受吡哆醇或安慰剂治疗的患者时没有出错；p小于0.0156。
